Electrical Diseases of the Heart: Genetics, Mechanisms, by A. A. M. Wilde, P. A. Friedman, M. J. Ackerman, W.-K. Shen,

By A. A. M. Wilde, P. A. Friedman, M. J. Ackerman, W.-K. Shen, Ihor Gussak, Charles Antzelevitch

This ebook presents a distinct modern and succinct distillation of the present prestige of lately delineated electric illnesses of the guts, emphasizing their universal and numerous scientific gains. the newest advancements within the box of experimental and medical cardiac electrophysiology, genetics, pharmacology and interventional cures of varied scientific arrhythmogenic entities are featured and mentioned by way of fresh advances in easy and medical technological know-how. The e-book is split into seven significant components. each one half involves chapters (total of sixty four) facing similar subject matters.

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J Physiol 1952; 117:500–544. 17. Armstrong CM, Bezanilla F. Currents related to movement of the gating particles of sodium channels. Nature 1973;242:459–461. 18. Woodbury LA, Woodbury JW, Hecht HH. Membrane resting and action potentials from single cardiac muscle fibers. Circulation 1950;1:265– 266. 19. Coraboeuf E, Weidmann S. Potentiel de repos et potentiels d’action du muscle cardiaque, mesurés à l’aide d’électrodes intracellulaires. Compt Rend 1949;143:1329–1331. 20. Weidmann S. The effect of the cardiac membrane potential on the rapid availability of the sodiumcarrying system.

Tissue distribution and functional expression of the human voltage-gated sodium channel beta3 subunit. Pflügers Arch 2001; 441:481–488. 25. Wang Z, Feng J, Shi H, et al. Potential molecular basis of different physiological properties of the transient outward K+ current in rabbit and human atrial myocytes. Circ Res 1999;84:551–561. 22 26. Decher N, Uyguner O, Scherer CR, et al. 3 potassium channels: Cloning and expression of a short hKChIP2 splice variant. Cardiovasc Res 2001;52:255–264. 27. Schotten U, Haase H, Frechen D, et al.

59 In addition, Purkinje fibers show spontaneous diastolic depolarization responsible for the idioventricular rhythm during atrioventricular dissociation. 3 channels are more expressed than in the 20 I. Baró and D. Escande ventricle (unpublished data). 2 are lower than in the ventricle, whereas TWIK1 is higher (unpublished data). 73 Cardiac Cellular Electrophysiology in Other Mammalians Computer Models of Cardiac Cellular Electrophysiology Because in the obvious difficulties in obtaining undiseased human myocardial cells, most electrophysiological and electropharmacological studies have been conducted in animal models.

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