By Raphael C. Wong, Harley Y. Tse
A finished overview of the technology of drug checking out in all its facets, putting emphasis on applied sciences that use physique fluids except urine for deciding upon the presence of gear of abuse. The authors talk about a number of the physique fluid specimens appropriate for checking out for illicit drugs-particularly saliva, sweat, and hair-describe the structural and production facets of on-site checking out units according to lateral move immunoassay, and element the pitfalls of utilizing those specimens. in addition they talk about intimately the matter of pattern adulteration and its detection. for the reason that oral fluid has the simplest strength of succeeding urine because the subsequent matrix of selection for drug detection, 4 well known saliva trying out units are tested: InterceptВ®, the Drager Drug TestВ®, OratectВ®, and Drugwipe. Political, social, and felony matters also are thought of in articles on privateness, using drug trying out in courts, and the matter of pattern adulteration.
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Additional resources for Drugs of Abuse. Body Fluid Testing
Determination of drugs of abuse in blood. J Chromatogr B Biomed Sci Appl 1998;713(1):91–109. 8. gov. 9. Kadehjian L. Performance of five non-instrumented urine drug-testing devices with challenging near-cutoff specimens. J Anal Tox 2001;25(8):670–679. 10. Willette R and Kadehjian L. Drugs-of-abuse test devices: a review, in On-Site Drug Testing (Jenkins AJ and Goldberger BA, eds), Humana Press, Totowa, NJ: 2002; pp. 219–252. 11. Cone EJ, Presley L, Lehrer M, et al. Oral fluid testing for drugs of abuse: positive prevalence rates by Intercept immunoassay screening and GC-MS-MS confirmation and suggested cutoff concentrations.
Semen Semen has been demonstrated to have measurable levels of drug after drug use. It is occasionally proposed as a basis to explain positive drug tests as a result of exposure to drugs through sexual relations. However, the absolute amount of drug present in semen is very low and could not account for significant exposure (61). 5. Nails Drugs are found in nails, as they are in hair. Nails have been used to detect drugs in both adults and neonates (62–65). 6. Vitreous Humor Vitreous humor is the gel that fills the eye.
Drug testing of meconium: determination of prenatal drug exposure, in Handbook of Analytical Therapeutic Drug Monitoring and Toxicology (Wong SHY and Sunshine I, eds). CRC Press, Boca Raton, FL: 1997; pp. 265–279. 58. Winecker RE, Goldberger BA, Tebbett IR, et al. Detection of cocaine and its metabolites in breast milk. J Forensic Sci 2001;46(5):1221–1223. 28 Kadehjian 59. Dickson PH, Lind A, Studts P, Nipper HC, Makoid M, and Therkildsen D. The routine analysis of breast milk for drugs of abuse in a clinical toxicology laboratory.