Controlled-Release Technology. Pharmaceutical Applications by Ping I. Lee and William R. Good (Eds.)

By Ping I. Lee and William R. Good (Eds.)

content material: evaluation of controlled-release drug supply / Ping I. Lee and William R. stable --
Microstructural types for diffusive delivery in porous polymers / W. Mark Saltzman, Stephen H. Pasternak, and Robert Langer --
Diffusion in heterogeneous media / Bret Berner, J.C. Keister, and Eugene R. Cooper --
Estimation of premiums of drug diffusion in polymers / C.G. Pitt, A.L. Andrady, Y.T. Bao, and N.K.P. Samuel --
Interpretation of drug-release kinetics from hydrogel matrices when it comes to time-dependent diffusion coefficients / Ping I. Lee --
Physicochemical types for percutaneous absorption / J. Hadgraft and Richard H. man --
floor chemical research of polymeric drug supply platforms through static secondary ion mass spectrometry (SSIMS) and SIMS imaging / M.C. Davies and A. Brown --
enhanced approach for measuring in vitro diffusion of gear via human pores and skin / L.R. Brown, J.F. Cline, C.L. Raleigh, and M.B. Henry --
Simplified method for measuring controlled-release kinetics / Charles G. Gebelein, Tahseen Mirza, and Robert R. Hartsough --
Thermally reversible gelation features : poly(oxyethylene)-poly(oxypropylene) block copolymer in aqueous resolution after publicity to high-energy irradiation / D. Attwood, C.J. Tait, and J.H. Collett --
free up and behind schedule liberate of water-soluble medications from polymer beads with low water swelling / Karl F. Mueller --
Morphine hydrogel suppositories : equipment layout, scale-up, and assessment / Marion E. McNeill and Neil B. Graham --
Use of bioerodible polymers in self-regulated drug supply platforms / J. Heller, S.H. Pangburn, and D.W.H. Penhale --
Polysaccharides as drug providers : activation methods and biodegradation reviews / Etienne Schacht, Filip Vandoorne, Joan Vermeersch, and Ruth Duncan --
Microspheres as controlled-release structures for parenteral and nasal management / S.S. Davis, L. Illum, D. Burgess, J. Ratcliffe, and S.N. generators --
bettering drug free up from polylactide microspheres by utilizing base within the microencapsulation method / Jones W. Fong, Hawkins V. Maulding, George E. Visscher, Josephine P. Nazareno, and Jane E. Pearson --
results of ethanol at the delivery of [beta]-estradiol in hairless mouse dermis : comparability of experimental info with a brand new theoretical version / W.I. Higuchi, U.D. Rohr, S.A. Burton, P. Liu, J.L. Fox, A.H. Ghanem, H. Mahmoud, S. Borsadia, and William R. sturdy --
Probing the constitution of stratum corneum at the molecular point / ok. Knutson, S.L. Krill, W.J. Lambert, and W.I. Higuchi --
New liposomal supply approach for managed drug unlock / Victoria M. Knepp, Robert S. Hinz, Francis C. Szoka, Jr., and Richard H. man --
greater absorption of ionizable medicinal drugs from topical dosage varieties / Tsuneji Nagai and Toyoaki Ishikura --
Transdermal drug supply procedure with better pores and skin permeability / Yei W. Chien and Chia-Shun Lee --
solution to improve intranasal peptide supply / Lawrence S. Olanoff and Richard E. Gibson --
Transbuccal absorption of diclofenac sodium in a puppy version / C.D. Ebert, V.A. John, P.T. Beall, and K.A. Rosenzweig --
Constant-release diffusion structures : expense keep watch over by way of geometric configuration / K.G. Nelson, S.J. Smith, and R.M. Bennett --
Disposable controlled-release equipment for drug infusion / Paul Y. Wang, Mary C.Y. Lee, and will S.M. Smith.

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A l t h o u g h t h i s e f f e c t can be r e d u c e d by i n c r e a s i n g the sample s i z e , t h e s e r e s u l t s demonstrate t h a t w i t h a manageable number o f images ( i . e . 18) and p r o f i l e s ( i . e . 491) s a t i s f a c t o r y r e s u l t s can be o b t a i n e d . A p p l i c a t i o n t o d r u g d e l i v e r y systems. T w e n t y - e i g h t images o f the EVA-lysozyme c h l o r i d e d r u g d e l i v e r y system were a n a l y z e d . The images were o b t a i n e d from s i x t e e n d i f f e r e n t s e c t i o n s from t h e m a t r i x ; m u l t i p l e images, r e p r e s e n t i n g independent f i e l d s o f view, were o b t a i n e d from f o u r o f t h e s e c t i o n s .

R e c e n t l y , t h e o r e t i c a l s t u d i e s o f t r a n s p o r t i n p o r o u s media have been i n v i g o r a t e d by t h e a p p l i c a t i o n o f p e r c o l a t i o n t h e o r y : a l i t e r a t u r e i n s t a t i s t i c a l p h y s i c s t h a t d e s c r i b e s d i s o r d e r e d media. Our E q u a t i o n (4) i s an e x p r e s s i o n o f dynamic p e r c o l a t i o n i n a network o f w a t e r - f i l l e d e v a l u a t e t r a n s p o r t phenomen p r o m i s i n g one.

16. ; J. Pharm. Sci. 1976, 65, 1574-1578. 17. ; J. Pharm. Sci. 1973, 62, 210-217. 18. ; Eds. John Wiley and Sons: New York, 1985, pp. 407-432. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1987. Chapter 4 Estimation of Rates of Drug Diffusion in Polymers C. G. Pitt, A. L. Andrady, Y. T. Bao, and Ν. K. P. O. Box 12194, Research Triangle Park, NC 27709 A method of estimating the solubility of drugs in rub­ bery polymers, based on the octanol-water partition coefficient of the drug, is described.

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