By Jie Jack Li, Douglas S. Johnson, Drago R. Sliskovic, Bruce D. Roth
Written by means of contributors of Pfizer worldwide learn and improvement for chemists getting into the pharmaceutical undefined, this paintings profiles the synthesis of fourteen consultant pharmaceutical items so that it will display the multidisciplinary nature of the undertaking. for every drug, they supply a old creation and the organic, pharmacological, pharmakinetic, and drug metabolism historical past ahead of detailing the drug's synthesis.
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Bertenshaw, S. ; Carter, J. ; Collins, P. ; Graneto, M. ; Lee, L. ; Malecha, J. ; Miyahiro, J. ; Rogers, R. ; Rogier, D. ; Yu, S. ; Anderson, G. ; Koboldt, C. ; Perkins, W. ; Veenhuizen, A. ; Zhang, Y. ; Isakson, P. C. J. Med. Chem. 1997, 40,1347-1365. 7. Talley, J. ; Penning, T. ; Collins, P. ; Rogier, D. ; Malecha, J. ; Miyashiro, J. ; Bertenshaw, S. ; Khanna, I. ; Granets, M. ; Rogers, R. ; Carter, J. ; Docter, S. ; Yu, S. S. WO 95/15316. 8. ; Gauthier, J. ; ThCnen, M. WO 95/18799. 9. Cutler, R.
Thus maintaining the equilibrium between HCl and the acid-neutralizing mucus is important for the gastnc system. Two types of drugs are utilized for neutralizing the excess acid produced in the GI tract: the first type are antacid salts, such as CaC03, NaHC03, and Alp04 whose mode of action is a simple acid-base neutralization; while the second type are inhibitors of acid production. The latter is evidently superior to the former due to lesser side effects. The inhibitor approach has produced many block-buster drugs that have revolutionized the pharmaceutical industry.
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