By Stewart Wolf, Allen K. Murray
The current quantity includes the edited transcript of a Totts hole Colloquium held could 19-21, 1980 subsidized by way of the Muscular Dystrophy organization. the purpose of the colloquium used to be to deliver into concentration information in terms of phone membranes that will give a contribution to realizing the pathogenic mechanism of Duchenne muscular dystrophy. a big obstacle to growth in figuring out the patho genesis of muscular dystrophy has been the failure, to this point, to spot the elemental genetic illness. Pending the id of the genetic lesion in Duchenne dystrophy and, in view of scattered yet chronic symptoms of a simple membrane disturbance, it appeared priceless to discover in open discussion the present country of information of membrane morphology and chemistry with a watch to attainable leads for additional research. The individuals, drawn from a number of disciplines, tried to synthesize and reconcile their findings and to spot the most important parts of lack of information short of exploration. For the main half they kept away from really expert jargon and spoke in a language that may be understood via the remainder of the crowd. except offering a assessment of broadly various techniques to the research of the composition and behaviour of mobile membranes, the discussions introduced jointly present think~g on options and ways to the learn of the pathogenesis of muscular dystrophy. Already the non-public contacts made on the colloquium have resulted in new inter-institutional collabora tive investigations.
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Additional resources for Composition and Function of Cell Membranes: Application to the Pathophysiology of Muscle Diseases
1978). Polyacrylamide gel patterns of Ught SR (gel 1) and heavy SR (gel 3) were compared with the normal SR (gel 2) from which they were derived (Figurel-l4). The electron opaque cOntents of heavy SR are preferable mainly to calcium-binding protein with the SR compartment. Light SR is essentially all membrane vesicles, of which the calcium pump protein comprises 90 per cent or more of the membrane protein. ne from heavy SR likewise consists mainly of calcium pump protein. Indeed, the SR membrane 'IDP OF SEPARA~ ca2+ ca2+ GEL- PUMP POOl'EIN- BINDl}l; PlUlEIN- Mss ProrEIN f TRACKING DYE- GEL 1 2 3 Figure 1-16: Polyacrylamide gel electrophoresis (PAGE) of SR.
Would you expect that itiwould not work or would you expect the full outer leaflet of the membrane to be acquired accessible for the exchange protein? DR. de KRUIJFF: The outer monolayer lipids will be exchanged to the outside of the vesicle and we believe that to fit this mechanism of the inverted micelles, we have flip-flop from the inside to the outside and thereby exposing the inner monolayer lipids to the external environment. DR. SANDRA: I guess what I am saying is that I do not consider that proof of the inverted micelle.
SANDRA: I would like to comment on the exchange protein experiment. If you incubate phospholipid exchange protein (PLEP) together with inverted micelle, is the exchange at an acceptable level? Would you expect that itiwould not work or would you expect the full outer leaflet of the membrane to be acquired accessible for the exchange protein? DR. de KRUIJFF: The outer monolayer lipids will be exchanged to the outside of the vesicle and we believe that to fit this mechanism of the inverted micelles, we have flip-flop from the inside to the outside and thereby exposing the inner monolayer lipids to the external environment.