Combinatorial Peptide and Nonpeptide Libraries: A Handbook by Günther Jung

By Günther Jung

Reference on compound libraries of peptides, for researchers in natural synthesis, biochemistry, biotechnology, pharmacology, medication, and scientific chemistry. vast assurance of man-made ways and applied sciences, mass spectrometry, and screening assays. forty seven members, 21 U.S.

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All isolated individual self-DeDtide linands and Dreviouslv reDorted T-helmr edtoDes fit to this seauence motif. 1 Synthetic Methods and the Variety of Peptide and Oligomer Libraries In addition to the complete review in Chapter 3, this introductory section is intented to give only a brief overview of the most essential characteristics of various peptide libraries and guides to the literature and corresponding chapters of this book. Peptide librariesare mixtures of peptides consisting of hundreds (up to millions and more) of single components which have defined characteristics: equal length, defined amino acid positions (0positions) and mix positions (Xpositions) [36, 371.

Heiduschka, W. Beck, G. Jung, W. Gopel, Sensors and Actuators 1995, B28, 85-94. (391 P. Heiduschka, W. Beck, W. Kraas, G. Jung, W. Gopel, Polymer Preprints 1995, 36, 80-81. 1401 P. Heiduschka, W. Gopel, W. Beck, W. Kraas, S. Kienle, G. Jung, Chem. , 1996, in print. G. Beck-Sickinger, G. Jung, Pharmac. Acta Helv. 1993, 68, 3-20. 1421 E. R. Felder, Chimia 1994, 48, 531-541. (431 M. C. Desai, R. N. Zuckermann, W. H. Moos, Drug Development Research 1994, 33, 174. (441 M. A. Gallop, R. W. Barrett, W.

2 Natural Peptide Libraries of Microbial Origin a tionally restricted a-aminoisobutyric acid (Aib), a N-terminal acetyl group and a Cterminal amino alcohol [13]. All form potential-dependent ion channels [14] in lipid bilayers membranes. They have mainly a-helical conformation, a proline bend and a high dipole moment. All natural amino acid exchanges (Fig. 1-1) occur with retention of these characteristic structural properties and therefore, there are few differences found in the biological activities of these variants.

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