By Peter Irving MD MRCP, Corey A. Siegel, David Rampton, Fergus Shanahan
Evidence-based information to respond to greater than 60 arguable scientific questions about inflammatory bowel diseaseClinical Dilemmas in Inflammatory Bowel illness is a pragmatic guide supplying quickly yet distinct solutions to the questions and demanding situations that you're confronted with day-by-day within the scientific setting.Each brief bankruptcy addresses a unique subject and offers evidence-based advice on topics starting from optimising present administration via to big administration difficulties and novel remedies. This e-book is appropriate for all doctors serious about the care of sufferers with IBD: validated and trainee gastroenterologists, colorectal surgeons, pathologists, radiologists, expert nurses, pharmacists, dieticians and counsellors
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Additional resources for Clinical Dilemmas in Inflammatory Bowel Disease
Gastroenterology 2003; 124: 1629–35. 15 Brandt L, Bernstein L, Boley S, Franks M.
Arguably the best data on hematologic adverse reactions IS MONITORING NECESSARY? to sulfasalazine come from a 1996 study involving over 10 000 patients . These patients were identiﬁed from the UK General Practice Research Database, all having IBD or rheumatoid arthritis treated with sulfasalazine. Only 4/6286 IBD patients on sulfasalazine had an adverse hematologic reaction (one-tenth of the risk in the arthritis patients). These ﬁndings have been supported by more recent work . The majority of sulfasalazine-associated hematologic side-effects occur within 3 months of starting treatment .
Clinical Dilemmas in Inflammatory Bowel Disease Edited by Peter Irving, David Rampton, Fergus Shanahan Copyright © 2006 by Blackwell Publishing Ltd Part 2 Medical Treatment: Making the Most of What We’ve Got – 5-ASA drugs 7 Is monitoring necessary? RAKESH SHAH & ALASTAIR FORBES LEARNING POINTS Monitoring • 5-Aminosalicylic acid (5-ASA) drugs are safe and well-tolerated • Monitoring for hepatic and renal dysfunction is probably sensible • We recommend: • Baseline full blood count, urea and creatinine and liver function tests • Full blood count, urea and creatinine and liver function tests 6-monthly for the ﬁrst 2 years of therapy (full blood count 3-monthly for the ﬁrst 6 months – sulfasalazine only) • Subsequent annual urea and creatinine sulfapyridine constituent and are generally better tolerated than sulfasalazine .