Cardiovascular Genetics and Genomics (American Heart by Dan M. Roden

By Dan M. Roden
This complete and concise presentation of genetic elements in heart problems and their reaction to remedy consolidates wisdom of this high-interest and rising subject. protecting huge parts of latest genomic medication and particular cardiovascular illnesses, this ebook is a needs to for someone looking to larger comprehend this quickly constructing box.
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Sample text
Genomewide scans of complex human diseases: true linkage is hard to find. American Journal of Human Genetics 2001; 69: 936–950. 64 Altshuler D, Daly M. Guilt beyond a reasonable doubt. Nature Genetics 2007; 39: 813–815. 65 Clayton DG, Walker NM, Smyth DJ et al. Population structure, differential bias and genomic control in a large-scale, case–control association study. Nature Genetics 2005; 37: 1243–1246. 66 Campbell CD, Ogburn EL, Lunetta KL et al. Demonstrating stratification in a European American population.
26 International Multiple Sclerosis Genetics Consortium. Risk alleles for multiple sclerosis identified by a genomewide study. New England Journal of Medicine 2007; 357: 851–862. 27 Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447: 661–678. 28 Ott J. Analysis of Human Genetic Linkage, 3rd edn. Johns Hopkins University Press, Baltimore, 1999. Chapter 2 A primer in statistical methods in genetics 31 29 Haines JL, Korf BR, Morton CC, Seidman CE, Seidman JG, Smith DR.
According to Burroughs et al. [6], three processes or mechanisms are involved in the polymorphisms–drug response interaction, namely drug metabolism, drug targets, and disease pathway. However, polymorphisms in drug metabolism are usually considered the most relevant because of their recurrence in many important therapeutic classes. This is especially true in comparison with the other two mechanisms, which may affect only one drug or one class of drugs [6]. Polymorphisms of drug metabolism can influence individual response to drug therapy as a result of highly variable plasma concentrations of the parent compound or its metabolites [15].