Cardiac regeneration and repair: Biomaterials and tissue by Ren-Ke Li, Richard D. Weisel

By Ren-Ke Li, Richard D. Weisel

Cardiac Regeneration and service, quantity reviews using biomaterials, on my own or mixed with telephone remedy, in delivering tissue-engineered constructs to fix the injured center and forestall or opposite center failure.

Part one explores the range of biomaterials on hand for cardiac fix, together with nanomaterials and hydrogels. extra chapters discover using biomaterials to augment stem phone treatment for restoring ventricular functionality and producing stem cell-modified intravascular stents. half specializes in tissue engineering for cardiac fix, together with chapters on decellularized biologic scaffolds, man made scaffolds, mobile sheet engineering, maturation of sensible cardiac tissue patches, vascularized engineered tissues for in vivo and in vitro purposes, and medical issues for cardiac tissue engineering. eventually, half 3 explores vascular home improvement, together with chapters highlighting aortic extracellular matrix home improvement, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels.

Cardiac Regeneration and service, quantity Two is complemented by means of an preliminary quantity overlaying pathology and remedies. jointly, the 2 volumes of Cardiac Regeneration and service provide a finished source for clinicians, scientists, or academicians excited about cardiac regeneration, together with these drawn to mobilephone treatment, tissue engineering, or biomaterials.

  • Surveys the range of biomaterials on hand for cardiac fix, together with nanomaterials and hydrogels.
  • Focuses on tissue engineering for cardiac fix together with scientific concerns for cardiac tissue engineering
  • Explores vascular home improvement, highlighting aortic extracellular matrix home improvement, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels

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7:1049–57. 20. Choi JS, Leong KW, and Yoo HS (2008). In vivo wound healing of diabetic ulcers using electrospun nanofibers immobilized with human epidermal growth factor (EGF). Biomaterials. 29:587–96. 21. Patel S, Kurpinski K, Quigley R, Gao HF, Hsiao BS, et al. (2007). Bioactive nanofibers: Synergistic effects of nanotopography and chemical signaling on cell guidance. Nano Lett. 7:2122–8. 22. Taek Gyoung Kim, and Park TG (2006). Surface functionalized electrospun biodegradable nanofibers for immobilization of bioactive molecules.

Nature. 462:426–32. 16. Chew SY, Mi RF, Hoke A, and Leong KW (2007). Aligned protein–polymer composite fibers enhance nerve regeneration: a potential tissue-engineering platform. Adv Funct Mater. 17:1288–96. 17. Luong-Van E, Grondahl L, Chua KN, Leong KW, Nurcombe V, and Cool SM (2006). Controlled release of heparin from poly(epsilon-caprolactone) electrospun fibers. Biomaterials. 27:2042–50. 18. Liao IC, Chew SY, and Leong KW (2006). Aligned core-shell nanofibers delivering bioactive proteins.

Several nanosensors have been developed to record these signals. For example, insufficient blood supply to the heart muscles with anaerobic metabolism, which leads to an increase of K+ efflux from the cardiovascular cells and decrease in pH. Detection of K+ and H+ concentration changes were initiators for the development of nanosensors. Li et al. 41 They used a multi-sensor silicon needle to conduct multimeasurement of ions such as K+, H+ and temperature on the myocardial tissue at the same time.

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