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Additional info for Cardiac Reconstructions with Allograft Tissues
Actuarial (Kaplan-Meier) freedom from valve reoperation for patients undergoing ascending aortic replacement (upper dashed line) and infra- coronary aortic valve replacement (circles). Reproduced from Kirklin with permission. 3. Actuarial and parametric freedom from presumed leaﬂet failure. This includes patients with aortic regurgitation by echo grade 3 or 4 (n = 4), patients undergoing explantation for leaﬂet failure (n = 4), or leaﬂet degeneration found at autopsy (n = 0), AR, aortic regurgitation.
Seating of the annulus without deformation. 2. Factors that have been found to lead to decreased durability of homografts:81 a. Older donor age. b. Dilated aortic root (unless corrected by aortoplasty). c. , Marfan’s syndrome and cystic medial necrosis. d. g. rheumatoid arthritis, lupus, etc). e. Technically imperfect implant, causing turbulent ﬂows. f. Prolonged storage of wet-stored allografts prior to use. g. Harsh sterilization, harvesting, or preservation techniques. 3. 27 a. Cardioplegia-myocardial protection.
J Thorac Cardiovasc Surg 1984;87:649–657. 94. DiCarlo D, Stark J, Revignas A, deLeval MR. Conduits containing antibiotic preserved homografts in the treatment of complex congenital heart defects. In Cohn LH, Gallucci V 13 95. 96. 97. 98. 99. 100. 101. 102. (eds). Cardiac Bioprostheses. New York: Yorke; 1982:259–265. DiCarlo D, deLeval MR, Start J. “Fresh,” antibiotic sterilized aortic homografts in extracardiac valve conduits: long-term results. Thorac Cardiovasc Surg 1984;32:10–14. Moore CH, Martelli V, Ross DN.