Blood Coagulation Disorders: Hemorrhagic Diatheses and by Prof. Dr. med. Fritz Reinhard Matthias (auth.)

By Prof. Dr. med. Fritz Reinhard Matthias (auth.)

Show description

Read or Download Blood Coagulation Disorders: Hemorrhagic Diatheses and Thromboembolic Diseases PDF

Best diseases books

Pain-Relieving Procedures: The Illustrated Guide

Powerful discomfort administration calls for more and more really expert wisdom. Multidisciplinary details is needed in case you intend to perform ache administration at a excessive point of effectiveness. This comprises anatomy and body structure, discomfort syndromes, analysis and administration, and the right kind use of interventional strategies.

Endoscopic Follow-up of Digestive Anastomosis

As a result of the changes in visceral anatomy, many endoscopists, and particularly trainees, event problems while acting endoscopic surveys or techniques in sufferers who've formerly passed through surgical procedure to the digestive tract. during this richly illustrated e-book, a professional within the box presents an in depth evaluation of endoscopic follow-up of gastrointestinal (esophageal, gastric, and colorectal) anastomosis.

Curbside Consultation in Endoscopy: 49 Clinical Questions

Are you trying to find concise, sensible solutions to questions which are usually left unanswered through conventional references? Are you looking short, evidence-based suggestion for classy situations or issues? Curbside session in Endoscopy: forty nine medical Questions offers quickly and direct solutions to the thorny questions ordinarily posed in the course of a “curbside session” among colleagues.

Non-Alcoholic Fatty Liver Disease: A Practical Guide

The pointy upward push in situations of Non-alcoholic fatty liver disorder is quick changing into one of many significant matters for hepatologists worldwide. This entire scientific consultant explains how you can diagnose NAFLD and deal with sufferers in response to the simplest criteria of care. participants from the world's leading associations pay attention to sufferer care, drawing on their wide event.

Extra info for Blood Coagulation Disorders: Hemorrhagic Diatheses and Thromboembolic Diseases

Sample text

16. Mechanisms of hemostasis A mild hemostatic disorder with moderate lowering of one or some coagulation factors can be compensated without manifest hemorrhagic diathesis occurring. Hemorrhages from capillaries stop mainly by compression and agglutination of the endothelial cells. With in juries of the arterial and venous vessels the hemostatic process progresses in several phases (Fig. 16): 1. Vascular lesion or endothelial damage with reflex vascular constriction. 2. Adhesion of thrombocytes to exposed subendothelial tissue, collagen and pervascular structures.

It is possible to quantify the fibrinogen/fibrin split products by: 1. tanned red cell hemagglutination inhibition immunoassay (TRCHII test, Wellcome) 2. latex agglutination test (Wellcome) 3. staphylococcal clumping test (Behringwerke, Boehringer) 4. Laurell electrophoresis 5. immune precipitation. To avoid interference with fibrinogen, the test must be carried out in the serum. There are possibilities of error in that some of the split products, particularly the macromolecular ones, are incorporated into the clot during production of the serum, and minimal amounts of fibrinogen or fibrin persist as complexes with split products dissolved in the serum.

The use of the Thrombotest and Normotest makes it possible to distinguish whether a reduction in the prothrombin complex factors is due to liver cell damage, vitamin K deficiency, or vitamin K antagonism due to coumarins. If the two tests are equally reduced, there is little or no PIVKA. Then probably one has liver cell damage. It should be mentioned that in hepatic cirrhosis also it is possible for the inactive precursors of the prothrombin complex (PIVKA) to be produced for various reasons. If the value in the Thrombotest is decidedly less than that in the Normotest, then a disorder of vitamin K metabolism is present.

Download PDF sample

Rated 4.28 of 5 – based on 10 votes