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It is also possible that ß-lactamases interfere with the passage of small molecules through the porins, possibly by affecting porin configurations and thereby altering penetrability characteristics. Therefore, inhibition of ß-lactamases by potent ß-lactam antibiotics may be a factor in certain specific cases of resistance. However, at this time other factors cannot be ruled out. More information concerning distribution of antibiotic inside and outside the cell must be established for these new agents before /3-lactamase inhibition may be definitively implicated as a major cause for resistance.