Analytical Profiles of Drug Substances and Excipients, Vol. by Harry G. Brittain

By Harry G. Brittain

Even if the respectable compendia outline a drug substance as to identification, purity, energy, and caliber, they usually don't supply different actual or chemical facts, nor do they record equipment of synthesis or pathways of actual or organic degradation and metabolism. Such info is scattered during the clinical literature and the documents of pharmaceutical laboratories. Analytical Profiles of Drug components and Excipients, brings the newest details jointly in a single source.•Represents a vital contribution to the perform of pharmaceutical research• offers a very good evaluation of actual, chemical, and biomedical houses of a few on a regular basis prescription drugs• each one quantity within the sequence features a cumulative index

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3 Nuclear Magnetic Resonance Spectrometry The lH and 13C nuclear magnetic resonance spectra of aspartame are shown in Figures 6 and 7, respectively. 5 mg/mL) using a Bruker Avance DRX-500 spectrometer. All spectra were referenced to tetramethylsilane, and assignments for the 1H-NMR and ~3C-NMR spectra are found in Tables 2 and 3, respectively. High resolution NMR studies, in combination with molecular mechanics, were performed to unequivocally assign the prochiral B-protons for the phenylalanine sidechain and to define the shape of the sweet receptor [49].

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