By Frederick W. Alt
Advances in Immunology, a usual and hugely revered e-book, provides present advancements in addition to finished stories in immunology. Articles deal with the wide variety of issues that include immunology, together with molecular and mobile activation mechanisms, phylogeny and molecular evolution, and medical modalities. Edited and authored by way of the major scientists within the box, every one quantity presents up to date details and instructions for the future.
* Contributions from major professionals * Informs and updates on the entire most recent advancements within the box
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Additional info for Advances in Immunology
2013). , 2013). , 2010). , 2013). Combined ablation of Rc3h1 and Rc3h2 in T cells induced the elevated expression of Ox40 and the activation of the alternative NF-κB pathway. It remains to be investigated through which molecular network Roquin regulates T-cell activation and Tfh differentiation and if the E3 ligase activity of Roquin is involved in mRNA regulation. It will be also important to find out what other mRNA and mRNA-associated substrates are regulated by the Roquin family proteins.
CYLD has been known to negatively regulate NF-κB activation in TCR signaling by removing K63-linked polyubiquitin chains from TAK1. , 2007). We recently reported that USP9X DUB plays a positive role for TCR-induced NF-κB activation via facilitating CBM complex formation (Park, Jin, & Liu, 2013). As there is still a lack of knowledge of DUBs that possibly play a crucial role in TCR-induced NF-κB signaling, future studies will be required to characterize and establish the role of DUBs. 4. Noncanonical NF-κB signaling: CD40 Engagement of a subset of TNFR family member, CD40 with its ligand CD40L on B cells activates noncanonical NF-κB signaling pathway in a ubiquitin–proteasome-dependent manner.
2004). Ubc13/Uev1A has been thought to play an important role for NF-κB activation in TCR signaling by catalyzing K63-linked polyubiquitin chains with TRAF6, which in turn activates TAK1 and IKK. , 2004). 4 See legend on next page 44 Yoon Park et al. , 2006). These results suggest a possibility that other E2 or E3 enzymes, which have either cooperative or alternative roles, may be involved in NF-κB activation in TCR signaling. Modulating CBM complex activity is also a critical part of TCRinduced NF-κB signaling.