Advances in Adrenergic Receptor Biology by Qin Wang

By Qin Wang

This quantity of present issues in Membranes makes a speciality of Adrenergic Receptor Biology, starting with a evaluate of prior successes and ancient views then extra discussing present normal developments in adrenic receptor reviews in a number of contexts. This booklet additionally comprises discussions of the position and courting of adrenergic receptors to diversified platforms and illnesses, developing Adrenergic Receptor Biology as a wanted, sensible reference for researchers.

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Extra resources for Advances in Adrenergic Receptor Biology

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V. VI. VII. VIII. IX. X. Overview Introduction General Considerations Regarding GPCR Organization Signaling Diversity in b-Adrenergic Receptors The Impact of Recent Crystal Structures on Our Understanding of Biased Signaling Larger Receptor Arrays A. bAR Homodimers B. bAR Heterodimerization C. bAR Interactions with Other Receptor Classes D. Interactions with G Proteins and Effector Molecules Ontogeny of bAR Signaling Systems Asymmetric GPCR Complexes Beyond the Paradigm of a Cell Surface Receptor Conclusions Acknowledgments References I.

Historical Perspective for Understanding of Adrenergic Receptors 17 Rosenbaum, D. , Lyons, J. , & Arlow, D. , (2011). Structure and function of an irreversible agonist-beta(2) adrenoceptor complex. Nature, 469, 236–240. Ross, E. , & Gilman, A. G. (1977). Reconstitution of catecholamine-sensitive adenylate cyclase activity: Interactions of solubilized components with receptor-replete membranes. Proc Natl Acad Sci USA, 74, 3715–3719. , & Lefkowitz, R. J. (1993). A mutation-induced activated state of the beta2-adrenergic receptor.

X. CONCLUSIONS The holy grail of molecular pharmacologists is to be able to target single pathways associated with a given GPCR. The current focus on pathway-selective, biased ligands is providing optimism that these approaches may actually work. However, until recently, we have focused on the orthosteric ligand-binding site, which cannot provide the necessary level of discrimination possible. , 2010 for a specific example). We would argue that targeting assembly of signaling complexes might actually provide an even more ‘‘selective’’ set of biased assembly modulators.

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